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Keto Chicken Alfredo Casserole is your ticket to a delicious, low-carb meal that’s perfect for any day of the week. It’s a great recipe that combines tender chicken, zucchini noodles, and a rich Alfredo sauce, all baked to golden perfection. Whether you’re following a ketogenic diet or just looking for a healthier comfort food option, this casserole is sure to delight your taste buds.

Overhead photo of keto chicken alfredo casserole with a serving spoon.

I’ve been cooking up a storm for over 30 years, starting as a kid who loved to experiment in the kitchen. Dealing with a gluten intolerance, I learned the value of homemade, healthy meals early on. My recipes, like this Keto Chicken Alfredo Casserole, are all about being nutritious, easy, and fitting into your busy life. They’re tried, tested, and true – perfect for anyone wanting to eat well without spending hours in the kitchen. 

❤️ Why You Will Love This Recipe

  • Low in Carbs: Perfect for those on a keto or low-carb diet, it’s packed with all the flavors without the carb overload.
  • Easy to Make: With straightforward steps and common ingredients, it’s a breeze to put together, even on busy weeknights.
  • Ultimate Comfort Food: Creamy, cheesy, and utterly satisfying, this dish hits all the right notes for a comfort food classic.
  • Versatile: It’s easy to switch up ingredients based on what you have on hand, making it a great recipe for any night of the week.
  • Family-Friendly: The whole family, including the kids, will love this cheesy, creamy delight. It’s a guaranteed way to please a crowd.
  • Perfect for Meal Prep: This cheesy low carb meal reheats beautifully, making it a fantastic option for meal prep or enjoying leftovers the next day.

🗝️ Key Ingredients & Substitutions

This delicious Keto Chicken Alfredo Casserole is not just tasty but also adaptable to what you have in your pantry. Here’s a rundown of the key ingredients and possible substitutions:

  • Alfredo Sauce: The star of the dish! My homemade creamy Keto Alfredo Sauce is the BEST, using cream cheese, parmesan cheese, heavy cream (i.e. heavy whipping cream), and garlic. If you’re in a pinch, a store-bought low-carb Alfredo sauce can work too, just be sure to check the label.
  • Boneless Skinless Chicken BreastsCooked and diced or shredded for convenience. You can substitute with rotisserie chicken or even leftover chicken for a quicker option. If I don’t have precooked chicken on hand, I like to make my Instant Pot Shredded Chicken. It’s super easy and fast!
  • ZucchinisSpiralized to mimic noodles, zucchinis keep this dish low in carbs. Alternatively, spaghetti squash or palmini noodles can be great substitutes.
  • Shredded Mozzarella: Adds that gooey, cheesy texture. Feel free to use other types of cheese like cheddar or a blend for a different flavor profile.
  • Bacon Strips: For a bit of crunch and smokiness. If you’re not a fan of bacon or want a lighter option, you can skip it or replace it with turkey bacon.

🥣 How to Make Keto Chicken Alfredo Casserole

1. Prepare the Zucchini

Start by transforming your zucchinis into noodles using a spiralizer. If they’re a bit long, just snip them into manageable lengths with kitchen scissors. Pop the zucchini noodles in the microwave for a minute. Then, spread them out in a casserole dish lined with paper towels. Gently press them with another paper towel to soak up extra moisture. This step is key to avoid a watery casserole.

2. Cooking the Meat

Next up, cook the bacon in a large skillet until it’s nice and crispy. This not only gives you delicious bacon but also leaves behind flavorful grease. If you’re using raw chicken, go ahead and cook it in the same skillet to soak up all that bacon-y goodness. If you’re short on time, pre-cooked chicken or rotisserie chicken is a great shortcut.

bacon frying in a pan

3. Assembling the Casserole

Now, the fun part! Grab a large baking dish (the same one you used earlier is great!) and spread a layer of that creamy Alfredo sauce on the bottom. Layer half of your zucchini noodles, chicken, bacon, and sprinkle a cup of mozzarella on top. Repeat these layers once more, finishing with a generous layer of sauce and cheese.

4. Baking to Perfection

Bake your casserole at 375°F for about 15 minutes, then crank up the heat to 480°F for the final 10 minutes to get a beautifully golden top. Let it rest for 10 minutes after taking it out of the oven – I know, the wait is hard, but it’s worth it! Garnish with fresh parsley if desired and dig in!

Serving spoon lifting keto chicken alfredo casserole from the dish.

🪄 Recipe Notes & Tips

To make sure your Keto Chicken Alfredo Casserole recipe turns out just perfect, here are some handy notes and tips:

  • Dry Zucchini Thoroughly: The key to avoiding a watery casserole is to make sure your zucchini noodles are as dry as possible. Don’t skip the microwaving and patting dry steps.
  • Chicken: Feel free to use boneless, skinless chicken thighs for a juicier flavor. If you’re using pre-cooked or rotisserie chicken, simply chop it up and layer it in.
  • Bacon: The bacon adds a nice crunch and flavor, but if you’re looking to cut down on fat, you can reduce the amount or omit it altogether.
  • Mozzarella: Mozzarella is great for that melty, cheesy goodness. However, if you’re feeling adventurous, try a blend of cheeses like gouda or provolone for a different taste.
  • Homemade vs. Store-Bought Sauce: While my homemade Alfredo sauce is recommended for the best flavor and control over the ingredients, you can use a store-bought low-carb version in a pinch. Just check the labels for any hidden carbs!

🫙 Storage Instructions

Leftovers of this Keto Alfredo Chicken Bake are just as delicious, if not more so, the next day! Here’s how to store them effectively:

  • Refrigerator: Store any leftovers in an airtight container in the refrigerator. They should stay fresh and tasty for up to 3-4 days.
  • Freezing Instructions: If you want to keep the casserole for longer, it freezes well too. Wrap it tightly or use a freezer-safe container. It can be stored like this for up to a month.
  • Reheating: When you’re ready to enjoy it again, you can reheat the casserole in the oven or microwave. If it’s frozen, let it thaw in the fridge overnight before reheating.
Abowl of keto chicken alfredo casserole with a fork.

🍽️ What Can I Serve With Creamy Chicken Alfredo Casserole?

Low-Carb Veggies

Try serving it with roasted vegetables like broccoli, cauliflower, or Brussels sprouts. The caramelization adds a lovely depth of flavor. A bit of olive oil, salt, pepper, and maybe some garlic powder is all you need to make these veggies shine.

Rice Options for the Keto Diet

If you’re missing the rice element in a casserole, cauliflower rice is a fantastic keto-friendly substitute. You can buy it pre-made or make it at home by grating cauliflower and giving it a quick sauté. Another great keto option is konjac noodles.

Keto-Friendly Bread

A slice of keto bread can be great for scooping up the creamy sauce. You can even find it in the grocery store these days!

❓ Frequently Asked Questions

Can I make this casserole ahead of time?

Yes, you can assemble the casserole ahead of time and store it in the refrigerator. Just bake it when you’re ready to eat.

Is this casserole suitable for a gluten-free diet? 

Absolutely! This recipe is naturally gluten-free, making it a great option for those with gluten sensitivities.

Can I add more vegetables to the casserole?

Of course! Feel free to add more keto-friendly vegetables like spinach, mushrooms, or bell peppers for added nutrition and flavor.

Is there a dairy-free alternative for the Alfredo sauce?

Yes, you can make a dairy-free Alfredo sauce using my vegan cream cheese recipe and adding a little extra almond milk to thin it out, and some fresh garlic and ground black pepper for an extra pop of flavor.

Overhead photo of keto chicken alfredo casserole.

😋 More Keto Casseroles You Will Love

Have you made this recipe? I’d love to know <3 Tag me (@makehealthyrecipes) on Facebook and InstagramPin it on Pinterest, and please give it 5 stars with a review below! Don’t forget to subscribe to the email list (top right of this page) for sparkly new recipes in your inbox.

📖 Recipe

Overhead photo of keto chicken alfredo casserole with a serving spoon.

Keto Chicken Alfredo Casserole

Bethany Galloway
Keto Chicken Alfredo Casserole is your ticket to a delicious, low-carb meal that's perfect for any day of the week. It's a great recipe that combines tender chicken, zucchini noodles, and a rich Alfredo sauce, all baked to golden perfection.
5 from 1 vote
Prep Time 15 minutes
Cook Time 25 minutes
Total Time 40 minutes
Course Main Course
Cuisine American
Servings 6 Servings
Calories 562 kcal

Ingredients
 
 

  • 3 Cups Alfredo sauce
  • 2 lbs chicken breasts cooked and diced or shredded (Instant Pot Shredded Chicken is my go-to, dice it or shred it)
  • 3 zucchinis spiralized or very thinly sliced (like noodles)
  • 2 cups Shredded Mozzarella
  • 6 bacon strips diced

Instructions
 

Prepare the zucchini:

  • Begin by spiralizing the zucchini into noodles. Use a pair of kitchen scissors to cut the zucchini into smaller pieces.
    3 zucchinis
  • Place the zucchini in a microwave-safe dish like a large bowl, and microwave it for one minute.
  • Lay paper towels in a large baking dish (ideally the one you’ll bake in later), and place the zucchini on top of it. Use another paper towel to gently press the extra liquid out. Return the zucchini to the bowl and discard the paper towels.

Prepare the meat:

  • Cook the diced bacon in a medium skillet over low-medium heat until crispy, about 10 minutes.
    6 bacon strips
  • (Optional) If your chicken isn't pre-cooked, dice raw chicken breast and cook it in the bacon grease. You can also cook chicken in the instant pot.
    2 lbs chicken breasts

Assemble:

  • Begin by spreading 1/2 cup of Keto Alfredo sauce over the bottom of a large baking dish.
    3 Cups Alfredo sauce
  • Top it with half of the zucchini, followed by half of the chicken, bacon, and 1 cup of mozzarella.
    2 cups Shredded Mozzarella
  • Pour 1 cup of Alfredo sauce over the ingredients followed by the remaining zucchini, chicken, and bacon.
  • Pour the remaining Alfredo sauce evenly over the ingredient, and evenly sprinkle over the remaining cup of mozzarella.

Bake:

  • Bake the Keto Chicken Alfredo Casserole at 375°F (190°C) for 15 minutes, followed by 480°F (250°C) for 10 minutes. It will be golden-brown on top when it’s ready.
  • Allow the casserole to rest for 10 minutes before digging in and serving!

Notes

  1. Dry Zucchini Thoroughly: The key to avoiding a watery casserole is to make sure your zucchini noodles are as dry as possible. Don’t skip the microwaving and patting dry steps.
  2. Chicken: Feel free to use boneless, skinless chicken thighs for a juicier flavor. If you’re using pre-cooked or rotisserie chicken, simply chop it up and layer it in.
  3. Bacon: The bacon adds a nice crunch and flavor, but if you’re looking to cut down on fat, you can reduce the amount or omit it altogether.
  4. Mozzarella: Mozzarella is great for that melty, cheesy goodness. However, if you’re feeling adventurous, try a blend of cheeses like gouda or provolone for a different taste.
  5. Homemade vs. Store-Bought Sauce: While my homemade Alfredo sauce is recommended for the best flavor and control over the ingredients, you can use a store-bought low-carb version in a pinch. Just check the labels for any hidden carbs!

Storage Instructions

  • Refrigerator: Store any leftovers in an airtight container in the refrigerator. They should stay fresh and tasty for up to 3-4 days.
  • Freezing Instructions: If you want to keep the casserole for longer, it freezes well too. Wrap it tightly or use a freezer-safe container. It can be stored like this for up to a month.
  • Reheating: When you’re ready to enjoy it again, you can reheat the casserole in the oven or microwave. If it’s frozen, let it thaw in the fridge overnight before reheating.

Nutrition

Calories: 562kcalCarbohydrates: 8gProtein: 48gFat: 36gSaturated Fat: 17gPolyunsaturated Fat: 7gMonounsaturated Fat: 10gTrans Fat: 0.03gCholesterol: 216mgSodium: 1385mgPotassium: 884mgFiber: 1gSugar: 5gVitamin A: 497IUVitamin C: 19mgCalcium: 213mgIron: 1mg
Keyword easy, keto, keto alfredo sauce, keto chicken alfredo casserole, low carb, zoodles, zucchini
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5 from 1 vote (1 rating without comment)

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